In defense of Academia
The Breslow saga
Interview with Scott Alexander
On Lockheed Martin's Skunkworks
An interview with the founder of Cyclarity, a company working on reversing atherosclerosis
On East Asian drinking culture
The ultimate lab leak debate
Why did supersonic airliners fail.
Supersonic airliners coming back
Casey Handmer on making fuel out of air
On David Sinclair, sirtuins, and resveratrol
Devon Zuegel, Jan Sramek, and MIke Solana on California Forever
A TV show: Three Body Problem
A song: Syr…
I just published this article in Asimov Magazine called Making Cells Young, go have a look! :)
Docusign has over 7000 employees. Someone on the internet periodically discovers this fact and wonder how could this be! What are those 7000 employees doing?
The first part to the "What are they doing" question is "Sales", but that's not the full answer. Per their latest 10K filing,
68% of their workforce is sales, marketing, and customer success so that's ~5000 of those
And then 1760 of the workforce, a 24% is engineering, product development and customer operations
Leaving sales a…
A critical(!) review of Scaling People, a book by Claire Hughes Jones that I liked (ie I liked both the book and the review) though I am not as critical as the review is. CHJ 's book remains one of the best attempts at making the tacit art of management legible.
What happened to the US machine tool industry?
Scott Alexander: Should the future be human?
Things you learn dating Cate Hall, and Cate Hall on agencymaxxing
Casey Handmer on Elon Musk
The promise of SGLT2 inhibitors
Menopause and longevity
Karuna T…
"The startup burnout to spirituality pipeline is strong for a reason.": A glimpse of absolute perfection
Short term twin study on the impacts of a vegan diet in healthy-ish patients. Compared to control, patients in the vegan diet saw decreases in fasting insulin, weight, and LDL cholesterol
FAQ on Lantern Bioworks, a biotech startup producing an oral probiotic that can prevent cavities for life
Scott's Beyond Abolish the FDA proposal
All the different kinds of cardiovascular disease, and how man…
The title of this post will spark some controversy. But it is, under a reasonable interpretation, not false, just spicy 🌶️.
It make sense to start from the perhaps less controversial view that "rapamycin is an aging drug" and explain why that is wrong as well.
My issue with those that talk about rapamycin as an "(anti)aging drug", or a "geroprotector" is that it's often unclear what of this is being said
There's a unified thing called aging that affects everything that goes wro…