Sasha Chapin on Enjoying Things and Being Sasha Chapin

Scott Alexander reviews The Body keeps the Score. I recently read the book, which makes claims that will sound familiar and even obvious to many people that have engaged with many forms of therapy, particularly the idea that events that happened in someone's childhood can affect their current mental health. But I learned there that the author of the book had to fight for psychologists to accept this! Seemingly once upon a time the idea was considered obvious (From Freud) and then the field overcorrected in the other direction, making it difficult to accept that indeed trauma is real (a case of scientific flip-flopping).

50 thoughts on DOGE

Inducing torpor in mice to slow down aging

Fix the hypothalamus, fix ovarian aging

Some speculation about the next few years re progress in AI, and some more bearish speculation on the same topic.

Semianalysis on advances in robotics

Chapman on how what he does is like and not like philosophy

The science of woo

The baby boom started before WWII, not after

How to test for LLM situational awareness

Who is Larry Ellison

A socratic dialogue over the utility of DNA foundation models

In defense of letting people explore their curiosity in research

On the death of IP in biotech. A thesis I've had for biotech for a while

A tweet from mine on a concrete way to speed up some aspects of biotech: making the FDA more deterministic

The gut health to depression pipeline

Fix the brain, fix fertility

Interview with the founder of DeepSeek (via Kipply)