An inside view via 19 cameras of the NYC restaurant Crown Shy (which I recommend, get the gruyere frites and the roasted short rib)

Curtis Yarvin's recent interview [transcript]. The interviewer's reaction near the beginning sums up part of mine "I'm asking you what you had for breakfast and you go "Well, since the dawn of time!!, just answers"+"I find the depth of background information obfuscating, instead of illuminating". Though I could see how his style of storytelling could be entertaining to many. Fun facts, I first came across his blog, Unqualified Researvations a while back (2010 perhaps?), I remember reading this post.

Will all our drugs come from China?

Six and a half failed startup attempts

The origin story of OnlyFans, also Aella on the same topic

One from the archives, by me from 2021 on wildfires

Various things that correlate with lifespan

The company I work for, Retro Biosciences, recently co-developed a model with OpenAI for protein design, GPT4-b micro (the name was my suggestion :). We are also raising 1 billion dollars.

Did you know there are gigantic 500mL syringes

The correlation between aging, obesity and inflammation, my explanation for why GLP1s seemingly help with every disease

Investing in a16z, the VC firm, seems to be underperforming the SP500 these days

Japan has the will to have nice things, the US does not.

Gentle Romance

Lies and fraud in Alzheimer's research (my own AD posts, for context)

"Self-awareness" in LLMs (ie they 'know what they know' and 'what they tend to do' purely from the training set)

A recent summary of Michael Levin's work

A third of Tiktok users (and half of Instagram's!) wish the platform didn't exist

In biotech if you are not a therapeutics company, eventually you will go bankrupt or become one, tales from one such case, Reverie Labs

Tech CEO becomes very rich when his company gets acquired, gets depressed (many such cases), goes on a vision quest to the Himalayas, joins DOGE, goes to Hawaii to learn physics, writes blogpost to narrate his story.

Cate Hall goes on a T journey

List of stuff that has bits of plastic in it

An introduction to David Chapman's thoughts

Dwarkesh visits China

The biology of getting jacked

The public goods curse of pharmacokinetics