Monoclonal antibodies against Abeta continue to have lackluster performance (I have a standing bet that this will continue) Rapamycin tested in a human clinical trial over 13 weeks on various strength endpoints, didn't work On Writing AI Constitutions Meditation-induced timelessness Why are young people having more colorectal cancer? Deep jhana

I just recorded a new podcast you can find here. It's my favorite one so far! Hope you enjoy it.

The use of the Forced Perspective Technique in Lord of the Rings To my surprise, OpenAI seemingly didn't get their money back for GPT5's training if one includes the costs of running the org. I have this longstanding (but not deeply examined yet) intuition that even though very useful, LLM labs might end up becoming like airlines even when they develop super intelligence: low market cap, low profit commodities. Anthropic as an untrustworthy organization, with some spicy discussion on LessWrong. My own take…

At a recent retreat, I found myself sitting on a cushion facing a wall while my meditation partner sat to my side, outside of my visual field and started reading to me "From You to Infinity", pointing-out instructions from Ken Wilber. The text is quite trippy to read. What happened next was quite intriguing and it was probably the most significant experience of my life thus far so I wanted to write down as much detail as I can remember here so I never forget what happened. First, I remember my bre…

"The Claude Constitution is a beautiful document. Incomplete and overly verbose in some ways, but in a necessary way", I said on Twitter. It is beautiful in that it is self-aware, transparent, honest, and embodies these virtues, which are the kinds of virtues it is trying to instill into the model itself. This, the idea that a text may embody the ideas it tries to convey, I find quite interesting. Coincidentally a book I recently started reading talks about the very same thing in the context of m…

Since the recent disappointingly small effects of monoclonal antibodies on Alzheimer's Disease (AD) progression, there has been lots of discourse around what the cause of Alzheimer's might be. "If not amyloid then what is it?", many wonder. What is the thing we have to remove? In cancer we remove cancer cells, in treating cardiovascular disease we aim to lower LDL particles and that massively lowers risk. If not amyloid, what is the LDL of Alzheimer's? In this post I argue that there is no answer…