Since the recent disappointingly small effects of monoclonal antibodies on Alzheimer's Disease (AD) progression, there has been lots of discourse around what the cause of Alzheimer's might be. "If not amyloid then what is it?", many wonder. What is the thing we have to remove? In cancer we remove cancer cells, in treating cardiovascular disease we aim to lower LDL particles and that massively lowers risk.
If not amyloid, what is the LDL of Alzheimer's?
In this post I argue that there is no answer…
Bacteria isolated from japanese tree frogs shown to work better in mice against cancer than doxorubicin or checkpoint inhibitors
CAR-T to treat cardiovascular disease
New proteomics clock, I wrote a brief thread with some commentary
On the (deranged, imho) economics of space-based data centers; Elon likes the idea but he'll be proven wrong on this one:
DSHR's blog, with an observation I had been thinking about for a while but not seen addressed elsewhere: accounting for Kessler syndrome
Scott Manley (1, 2)…
Nasa's orion is flaming garbage
Looks like the AI 2027 report scenario isn't happening and money is running out, fundraising is no longer enough, and large debt raises are now happening. Derek Thompson and Tim Lee on AI bubble discourse.
In what sense is life suffering? (related)
Oakland guy makes klein bottles, stores them under his houses, retrieves them with a custom RC mini forklift
A critique of Nucleus Genomics
The end of progress against extreme poverty: sub-saharan african economies are not growing
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Book Review of Breakneck from Noah Smith, endorsed
On China and rare earths
Rotating detonation engines
Progress in pan-cancer therapy
DOGE and its consequences in the federal government
The AI revolution in radiology that never was
Pictures of the old and new colliding (bonus)
Learning fashion like an engineer
On testosterone measurement
Huel is fine to drink, despite the high lead allegations. Here a trustworthy Huel enjoyer shows his blood tests.
Towards Consciousness Engineering
You can survive on one k…
I just turned 33 and thought:
What are some lessons I keep coming back to?
What would I have told my younger self?
Each of this could take an entire post to unfold and I don't expect them all to make sense to you. To some extent these say more about me than they say about the rest of the world. Don't take them as advice to follow, but meditating on their truth may be useful to you.
Turns out it’s possible to talk to people for reasons other than learning new facts about the world. Some call this ‘vibing’…
One of the reasons I like living in the Bay Area are the social occasions one rarely finds anywhere else. One such recent one I attended was Slutcon (more on the event here). When I first saw the event announcement showing up on twitter, I bought tickets without thinking it twice. A heuristic I live by is living as if you're the main character in some novel and do what would go along with the overarching story while being fun to read. And in this case the plot demanded that I go.
I didn't feel like writing …