Bacteria isolated from japanese tree frogs shown to work better in mice against cancer than doxorubicin or checkpoint inhibitors

CAR-T to treat cardiovascular disease

New proteomics clock, I wrote a brief thread with some commentary

On the (deranged, imho) economics of space-based data centers; Elon likes the idea but he'll be proven wrong on this one:

  • DSHR's blog, with an observation I had been thinking about for a while but not seen addressed elsewhere: accounting for Kessler syndrome
  • Scott Manley (1, 2)
  • Andrew McCalip and thread

Scott Aaronson: "[seeking understanding of the universe] It’s self-indulgent, a few steps above spending my life learning to solve Rubik’s Cube as quickly as possible, but only a few". The comments are also an interesting read.

On peptides, from Eric Topol

On mechanistic interpretability of LLMs as a dead end

Progress in predicting binding affiniy of small molecules to proteins

Amanda Askell answers various philosophical questions about LLMs

Vagus nerve stimulation, in a phase 3 clinical trial, helps with rheumathoid arthritis, making this FDA approved. Score one for the woo claim that the mind influences what otherwise might be thought of as merely biological processes, disconnected from thoughts. To the contrary, the brain is not only concerned with cognition or locomotion but rather most things that happen in the body!

How are LLMs trained these days (as of 2024 at least)

An explanation of the phenomenon of grokking in LLMs

Butoh, a quaint japanese dance form

Olms, similar to Axolotls are salamanders that are extremely long lived and have regenerative capacities

A deeply moving post from Aella on the death of her mom

Hyperscaler free cash flow is running dry after all that spending on AI Capex

Review of LLM progress in 2025