Lithium orotate seems to help with Alzheimer's

Electronics components have gotten very very cheap in the past few decades

On LLM adoption from Zvi Mowshowitz

On the wild stories where someone that gets an organ transplant sometimes experience personality changes, and single cell learning.

HIV drugs as potential anti-aging drugs

Upcoming book about industrial efficiency

Alternative to LASIK coming?

A first person report of participating in a Phase 1 clinical trial

In defense of the Amyloid hypothesis (See previous Nintil posts on Alzheimer's too, though they may be out of date by now). The linked post in Astral Codex Ten is I think mistaken, and one can point to Alnylam's recent failure (No NfL change->no neurodegeneration slowdown) as a more solid test than perhaps the antibodies. It is nonetheless a good presentation of the amyloid cascade hypothesis and why it makes so much sense that amyloid beta is in some way in the etiology of Alzheimer's. The idea that very early prevention could slow down the appearence of AD does make sense to me, but once the disease starts one has to intervene at a different place to stop it. The company I work at is testing a drug for AD later this year in Phase 1, we shall see how that goes!

Epigenetic proxies for health biomarkers like LDL fail to pick up changes in a randomized control trial

It is argued here that IQ decline happens much slower than commonly assumed.

From adderall skeptic to adderall enjoyer