Is erithrytol bad? Is aspartame bad?

As I noted in my Alzheimer's series, a promising target to treat the disease is phosphoryated tau (the 'fire' the keeps the disease burning) as opposed to amyloid beta (the 'spark' that triggers AD but does not keep it going). A recent attempt at reducing tau

A reason why microbiome research is widely thought to be not of high quality: Small variations to sample preparation techniques seem to have large effects on the bacteria that end up being analized

"Fake work" in the tech industry

Sirtuins and longevity

The rationalist guide to interior design

On HVAC private equity (a meme)

Me on Oppenheimer and management

2023 in science

Does CO2 affect cognition?

A plea for the FDA to let patients self-experiment more, from a terminal squamous cell carcinoma patient

Running a search fund

Michael Nielsen on creative research work. Some points reminiscent of a recent book I read

AI for cell therapy

Svyatoslav Nikolayevich Fyodorov, doing eye surgery on a boat

Two years of Impetus Grants

Jonathan Blow is not enthused about category theory

How to run an unconference

Designing entire CPUs with AI