A roundtable on Richard Hamming
A call for a new World Fair
Some social science bashing coming from social scientists Andrew Gelman
Private cities in China
Fusion startups continue to make progress
Spencer Greenberg on self-control
The New Space Race, with some cost charts
In case you are not a TFP nihilism convert yet (or at least take seriously the idea that TFP is not technology, or innovation), long-lasting negative TFP growth.
Lowering the cost of the preclinical stages by 20% or making them 20% faster (which to a certain degree are the same thing) does indeed save you money. . .but those are overwhelmed by the savings that you could realize if you could just reduce the clinical failure rate by 20%. The absolute best ways to do that would be through picking better targets and through picking compounds and targets that don’t throw up unexpected toxicity in humans. Those, sadly, are exactly the areas that AI/ML approaches are currently making the least traction in, because it’s so hard to think up a useful way to attack them. Speeding up screening or estimating physical properties, for all their difficulties, are so much more tractable. Which accounts for the press releases talking these up as if they’re removing gigantic stumbling blocks to fast and easy drug discovery.
DNA damage as a major cause of aging (In my original Longevity FAQ I had understated how relevant this could be)
Inequality in the US is decreasing, once once accounts for taxes and transfers
Matt Clancy on science causing more innovation, looking at a series of natural experiments
Brian Heligman's list of important problems to work on
Sponges don't care about your cancer-inducing doses of radiation
Want some movie recommendations? Thread
Progress in organdies; now we can make cells cry
Progress in artificial wombs
How do VCs make decisions?
Being a teenager during the collapse of the USSR
Fixing the scientific back burner
Alon Levy on how to drive down the costs of infrastructure in the US
Michael Nielsen asks: Who is the world's best scientific funder?
Biotech for the Biocurious
The success of NASA's COTS
Why did the covid vaccines take so long?
Interview with Jonathan Blow
Will Rinehart's links pos
I ask Twitter "What is the most inspiring thing you have ever read"
One of the problem with the current scientific environment
I keep waiting for America's libertarian moment. We'll know it has arrived when pay toilets return.
Lots of videos about Tesla's new battery technology
Book review of "A Thousand Brains"
Beware what sounds insightful
DNA origami: A review
What's wrong with Eric Weinstein's theory of everything
Liquid olives and iPhones
A case against nuclear energy (On the basis of cost). This seems mostly right, but it still makes sense to have a % of the electricity grid be nuclear or geothermal for base loading because when intermittent sources of energy increase in share, they stop being so appealing due to increased energy storage costs.
Capturing scientific knowledge in computable form