On the statistics of individual variations of productivity in research laboratories
Everything you always wanted to know about saturated fat
Peter Mitchell and the ox phos wars, when OXPHOS was controversial
Langmuir on pathological science
Sydney Brenner "How academia and publishing are destroying scientific innovation"
What people don’t realise is that at the beginning, it was just a handful of people who saw the light, if I can put it that way. So it was like belonging to an evangelical sect, because there were so few of us, and all the others sort of thought that there was something wrong with us.
They weren’t willing to believe. Of course they just said, well, what you’re trying to do is impossible. That’s what they said about crystallography of large molecules. They just said it’s hopeless. It’s a hopeless task. And so what we were trying to do with the chemistry of proteins and nucleic acids looked hopeless for a long time. Partly because they didn’t understand how they were built, which I think we molecular biologists had the first insight into, and partly because they just thought they were amorphous blobs and would never be able to be analysed. [...]
“A Fred Sanger would not survive today’s world of science. With continuous reporting and appraisals, some committee would note that he published little of import between insulin in 1952 and his first paper on RNA sequencing in 1967 with another long gap until DNA sequencing in 1977. He would be labelled as unproductive, and his modest personal support would be denied. We no longer have a culture that allows individuals to embark on long-term—and what would be considered today extremely risky—projects.”
Some success in using CRISPR to target cancers (Including the nastiest of them all, glioblastoma multiforme) in mice
What used to take a US supercomputer (Joule 2.0) built ~ 2018 now can be done by a single huge chip.
Genetic circuits for precision immunotherapy
My favorite anti-aging intervention, partial reprogramming, now applied to the brain of aged mice.
Progress in making cheap hydrogen. This matters because cheap hydrogen is the key to affordable hypersonic airplanes among other things.
At last, room-temperature superconductivity (At extremely high pressures)
Self-replicating antiviral molecular machines (!)
Michael Levin's two volume Ahead of the curve, reviewing old papers that were ignored when first released but that turned out to be important or that may turn out to be. Intriguingly here mitogenetic radiation appears as an underrated discovery while Langmuir above classifies this as pathological science. With frontier science this is not that surprising.
Electric storage keeps getting cheaper
How much does it cost to test compounds in vitro, test in animals, house mice, etc.
How "possibly" becomes a fact
Tanner Greer on substack
Josh Mitteldorf on that recent hyperbaric anti-aging therapy
Dietz Vollrath and Eli Dourado on economic gowth and stagnation
IMO scores seem to predict well mathematical achievement
Effective theory and Mercury's anomalous perihelion precession, an alternate history to the development of General Relativity.
A rapamycin clinical trial for longevity. At last!
RNA as a universal computer. With some examples.
Turbocharged CAR-T with multiple base edits
Bayh-Dole is a law that stipulates what federal agencies must include in a patent rights clause in a funding agreement. Those clauses establish the conditions upon which an owner of a subject invention is permitted to retain ownership. But Bayh-Dole does not require that any federal agency actually enforce any of those clauses. Thus, Bayh-Dole looks good (sorta) but ends up in practice being a do WTF you want law, but with useless administrative overhead (such as duplicating the reporting inventions and the like).
Michael Nielsen's Principles of Effective Research
Myths about naked mole-rat biology
Epigenetics also at the root of cancer?
Why tunnels in the US are so expensive
The second decade of synthetic biology
Full-text search anything
A writer on the censorship she suffered from various parties (Amazon, media) after the publication of her book on gender transition
Highly targeted senolytics
No X-ray crystallography? No problem
Apple's insanely fast M1 chip, benchmarked.
20% of Singapore's energy will be provided by a massive (50 square miles) 10GW solar power station in Australia.
Getting a Nobel Prize doesn't mean you are not a purveyor of fake news and scientific fraud.