Stuart Buck's personal metascience history
Heidi Williams on accelerating scientific progress
Claire Hughes Johnson interview
Ben Reinhardt on K-99
The placebo effect, less real than it originally seemed
The allele in the DEC2 gene that lets humans sleep less (which I have!) makes flies also sleep less -and- live longer
Pooled screens meets microscopy
Novo Nordisk (Ozempic, Wegovy)'s market cap is not larger than its home country (Denmark)'s GDP
Self-coercion, a thread
For a long time I assumed calling peop…
Is erithrytol bad? Is aspartame bad?
As I noted in my Alzheimer's series, a promising target to treat the disease is phosphoryated tau (the 'fire' the keeps the disease burning) as opposed to amyloid beta (the 'spark' that triggers AD but does not keep it going). A recent attempt at reducing tau
A reason why microbiome research is widely thought to be not of high quality: Small variations to sample preparation techniques seem to have large effects on the bacteria that end up being analized
"Fake work&q…
Scott's links post. A highlight is (13), an adversarial collaboration on whether there is gender bias in academic science (in hiring, grant funding, teacher ratints, salaries, etc).
Slow, Costly Clinical Trials Drag Down Biomedical Breakthroughs
Sasha Chapin on MDMA therapy
Chalmers wins long time running bet on whether consciousness would be understood by now
Matt Clancy and Tammy Besiroglu on AI and explosive growth
A weird fossil-inspired mansion in Joshua Tree
An economic analysis of Varda, the space ma…
Note: What's discussed in this post will seem extremely niche to most people, but the links throughout the post add the necessary context, so make sure to read those! If you want to read something before reading anything else, read this with particular attention to what is said there about "situational awareness".
AI risk discourse is so back, and I haven't blogged in a while, so now it's a good time, there was something I've been thinking about for months that I had to put in writing at some poin…
Review on the role of the microbiome and gut barrier dysfunction in aging
Gene therapy, now available in cream format
On post rationalists
DOE funding research in LENR ("cold fusion")
Building a better NIH
Patrick Collison interviews Sam Altman
Good critique of a16z's dishonest State of Crypto report
Treating sarcopenia with AAV
Shake a mouse's brain with ultrasound, get them to sleep and reduce their body temperature
Derek Lowe on the recent collapse of BenevolentAI (related tweet by me)
Small LL…
Per one of the few people working at the intersection of LLMs and cybersecurity, we're far from everything getting hacked by AutoGPTs. Related: Microsoft Security Copilot
Most US colleges have abandoned standardized testing. Mistakenly.
Movies that "go hard"
Mitigating the role of age-related somatic mutation burden
Sarah Constantin on AI Doomerism. TLDR: AGI is further away than the doomers think (And I agree).
In contrast, Richard Ngo's list of predictions for AI in 2025. One of them im particul…